Serveur d'exploration Stress et Covid

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Ghrelin-reactive immunoglobulins and anxiety, depression and stress-induced cortisol response in adolescents. The TRAILS study.

Identifieur interne : 000D38 ( Main/Exploration ); précédent : 000D37; suivant : 000D39

Ghrelin-reactive immunoglobulins and anxiety, depression and stress-induced cortisol response in adolescents. The TRAILS study.

Auteurs : Marie François [France] ; Johanna M. Schaefer [Pays-Bas] ; Christine Bole-Feysot [France] ; Pierre Déchelotte [France] ; Frank C. Verhulst [Pays-Bas] ; Sergueï O. Fetissov [France]

Source :

RBID : pubmed:25562566

Descripteurs français

English descriptors

Abstract

Ghrelin, a hunger hormone, has been implicated in the regulation of stress-response, anxiety and depression. Ghrelin-reactive immunoglobulins (Ig) were recently identified in healthy and obese humans showing abilities to increase ghrelin's stability and orexigenic effects. Here we studied if ghrelin-reactive Ig are associated with anxiety and depression and with the stress-induced cortisol response in a general population of adolescents. Furthermore, to test the possible infectious origin of ghrelin-reactive Ig, their levels were compared with serum IgG against common viruses.

DOI: 10.1016/j.pnpbp.2014.12.011
PubMed: 25562566


Affiliations:


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<term>Adolescent</term>
<term>Anxiety (metabolism)</term>
<term>Depression (metabolism)</term>
<term>Female</term>
<term>Ghrelin (immunology)</term>
<term>Humans</term>
<term>Hydrocortisone (metabolism)</term>
<term>Immunoglobulins (blood)</term>
<term>Influenza, Human (immunology)</term>
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<term>Facteurs sexuels</term>
<term>Femelle</term>
<term>Ghréline (immunologie)</term>
<term>Grippe humaine (immunologie)</term>
<term>Humains</term>
<term>Hydrocortisone (métabolisme)</term>
<term>Immunoglobulines (sang)</term>
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<div type="abstract" xml:lang="en">Ghrelin, a hunger hormone, has been implicated in the regulation of stress-response, anxiety and depression. Ghrelin-reactive immunoglobulins (Ig) were recently identified in healthy and obese humans showing abilities to increase ghrelin's stability and orexigenic effects. Here we studied if ghrelin-reactive Ig are associated with anxiety and depression and with the stress-induced cortisol response in a general population of adolescents. Furthermore, to test the possible infectious origin of ghrelin-reactive Ig, their levels were compared with serum IgG against common viruses.</div>
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